Research Article
MTHFR Gene Polymorphism and Age of Onset of Schizophrenia and Bipolar Disorder
Table 2
Genotype and allele frequencies of the C677T SNP in the control, bipolar, and schizophrenia groups.
| | | Control | Bipolar | Schizophrenia | Bipolar-control | Schizophrenia-control | | | ( = 149) | ( = 134) | ( = 103) | OR (CI) | Pearson
(df = 2) | value | OR (CI) | Pearson
(df = 2) | value |
| | Genotype: | | | | | | | | | | | CC | 114 (76.5%) | 46 (34.3%) | 52 (50.5%) | 0.16 (0.095–0.27) | 51.1 | 0.000* | 0.313 (0.182–0.538) | 18.35 | 0.000* | | CT | 30 (20.1%) | 70 (52.3%) | 36 (35%) | 4.34 (2.57–7.33) | 31.8 | 0.000* | 2.131 (1.21–3.77) | 6.917 | 0.009 | | TT | 5 (3.4%) | 18 (13.4%) | 15 (14.6%) | 9.47 (1.61–12.4) | 9.6 | 0.002 | 4.91 (1.72–13.98) | 10.47 | 0.001 | | Hardy-Weinberg equilibrium | = 2.66
= 0.103 | = 1.15
= 0.2844 | = 0.91
= 0.339 | | | | | | |
| | Allele frequencies: | | | | | | | | | | | C | 258 (96.3%) | 162 (81.8%) | 140 (82.4%) | 0.17 (0.08–0.36) | 26.73 | 0.000 | 0.18 (0.09–0.38) | 24.3 | 0.000 | | T | 40 (14.9%) | 106 (53.5%) | 66 (38.8%) | 6.57 (4.24–10.17) | 78.9 | 0.000* | 3.62 (2.29–5.71) | 32.4 | 0.000* |
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Significance ( < 0.05). OR: odd ratio. CI: confidence interval.
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