Drug Resistance Mechanisms of Mycoplasma pneumoniae to Macrolide Antibiotics

Table 2

Sequencing results of a part of clinically isolated strains.

Specimen number	Ribosomal protein L4							Ribosomal protein L22				23S ribosomal RNA
	58	66	81	140	162	209	430	62	65	279	508	Domain II	Domain V
N129	C	T	G	A	C	A	A	C	T	T	T	—	—
FH	—	—	—	—	C→A	—	A→G	—	—	T→C	T→C	—	—
1	—	—	—	—	C→A	—	A→G	—	—	T→C	T→C	—	A2064G
19	—	—	—	—	C→A	—	A→G	—	—	T→C	T→C	—	A2063G
75	—	—	G→T	—	—	—	—	—	—	—	—	—	A2064G
147	—	—	—	—	—	—	—	C→A	—	—	—	—	A2063G
216	—	—	—	—	—	—	—	—	T→A	—	—	—	A2063G
221	—	T→G	—	—	—	—	—	—	—	—	—	—	A2063G
223	—	—	—	—	—	—	—	C→A	T→A	—	—	—	A2063G
246	C→A	—	—	—	—	—	—	—	—	—	—	—	A2063G
255	—	—	—	—	—	—	—	—	T→A	—	—	—	A2063G
262	—	—	—	—	—	—	—	C→A	T→A	—	—	—	A2063G
277	—	—	—	—	—	—	—	C→A	T→A	—	—	—	A2063G
340	—	—	—	—	—	—	—	—	T→A	—	—	—	A2063G
355	—	—	—	—	—	—	—	—	T→A	—	—	—	A2063G
371	—	—	—	—	—	A→T	—	—	—	—	—	—	—
MEN20	—	—	—	—	C→A	—	A→G	—	—	T→C	—	—	—
MEN29	—	—	—	—	C→A	—	A→G	—	—	T→C	—	—	—
MEN30	—	—	—	A→C	C→A	—	A→G	—	—	T→C	—	—	—

Note: — represented no base mutation by comparing with the corresponding sequences of M129 that NCBI has registered; 1, 19, 75, 147, 216, 221, 223, 246, 255, 262, 277, 340, and 355 were all clinically isolated resistant strains, while 371, MEN 20, MEN 29, and MEN 30 were the sensitive strains. M129 and FH were the standard strains and MP gene sequences registered in NCBI gene bank were based on M129.