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Authors | Title | Year | Intervention | Patients included | Study design | Study endpoints | Reference |
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Øvrum et al. | A prospective randomized study of 1440 patients undergoing coronary artery bypass grafting | 2004 |
Blood versus crystalloid | 1.440* | Prospective randomized | Operative variables1, inotropic support, ICU/hospital stay, arrhythmias, stroke, mortality | [11] |
Ovrum et al. | A prospective randomised study of 345 aortic valve patients | 2010 | 345* | Prospective randomised | [12] |
Guru et al. | Is blood superior to crystalloid cardioplegia? A meta-analysis of randomized clinical trials | 2006 | 5.044* | Meta-analysis | LOS, MI, CKMB at 7 h, 24 h, 48 h | [13] |
Vhsilta et al. | Cardiomyocyte apoptosis after antegrade and retrograde cardioplegia during aortic valve surgery | 2011 |
Antegrade versus retrograde | 20* | Prospective randomised | Cardiomyocyte apoptosis (TUNEL assay, caspase 3, BCL-2, and BAX via ventricular biopsies upon reperfusion) ECHO | [19] |
Lotto et al. | Myocardial protection with intermittent cold blood during aortic valve operation: antegrade versus retrograde delivery | 2003 | 39* | Prospective randomised | Biopsies 20 min after cross-clamp removal, adenine nucleotide metabolites, lactate, troponin I | [20] |
Radmehr et al. | Does combined antegrade-retrograde cardioplegia have any superiority over antegrade cardioplegia? | 2008 | Antegrade plus retrograde | 87* | Prospective randomised | Inotropic support morbidity, ICU/hospital stay, mortality | [21] |
Fan et al. | Does combined antegrade-retrograde cardioplegia have any superiority over antegrade cardioplegia? | 2010 |
Warm versus cold | 5.879* | Meta-analysis | LOS, inotropic support, MI, stroke, arrhythmias, cardiac index, Troponin, CKMB | [22] |
Mallidi et al. | The short-term and long-term effects of cold or tepid cardiopelgia | 2003 | 6.064* | Prospective cohort | MI, Mortality | [23] |
Caputo et al. | Warm blood hyperkalaemic reperfusion (hot shot) prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgery | 1998 | Cold-cold plus hot-shot | 35* | Prospective randomised | Adenine nucleotide metabolites, alanine-glutamate ratio, lactate, troponin I: 5 min after begin of bypass, 30 min after arrest and 20 min after reperfusion | [25] |
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