Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21

<table>Macroscopic observation of joint swelling in rats with CIA. Arthritis was induced in 30 rats by treatment with type II collagen (5 normal rats as control), and the disease was scored clinically 3 times per week by the same person. (a) Normal rats, (b) arthritis onset of CIA model rats, and (c) the severity of arthritis clinical scoring. Differences between the control group and the model group were statistically significant (<svg height="11.375" id="M2" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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BioMed Research International

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Figure 1

Figure 1: Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21 