Gla-Rich Protein Is a Potential New Vitamin K Target in Cancer: Evidences for a Direct GRP-Mineral Interaction

Figure 3

GRP accumulates in healthy skin and mammary gland tissues. Immunolocalization of total GRP was performed with the CTerm-GRP antibody in healthy skin (a–c) and mammary gland (d) tissue sections. In skin, GRP accumulates at the epidermis (Ep) and blood vessels (BV) (a), sweat (SwG, b) and sebaceous (SG, c) glands. In mammary gland, GRP accumulates in the cytoplasm of ductal cells (DC) forming the lobules (d). NC represents negative controls performed by omitting the CTerm-GRP antibody in consecutive tissue sections. Samples were counterstained with haematoxylin. Scale bar represents 100 μm.