Gla-Rich Protein Is a Potential New Vitamin K Target in Cancer: Evidences for a Direct GRP-Mineral Interaction

Figure 8

cGRP and ucGRP are highly accumulated at sites of microcalcifications in BCC and IDC. Sites of cGRP (a, b, c) and ucGRP (d, e, f) accumulation were determined by IHC in BCC (a, d) and IDC (b, c and e, f) tissue sections, using the c/ucGRP antibodies. Both GRP protein forms are highly accumulated at sites of mineral deposits in all BCC and IDC calcification-containing samples analyzed. White arrows show examples of microcalcifications; sections were counterstained with haematoxylin. Scale bar represents 100 μm.