A Novel Strategy for Inducing the Antitumor Effects of Triterpenoid Compounds: Blocking the Protumoral Functions of Tumor-Associated Macrophages via STAT3 Inhibition
Figure 3
Antitumor effects of corosolic acid in the LM8-injected mice model. Protocol for administering corosolic acid (CA) and implanting LM8 (a). Effects of corosolic acid (CA) on subcutaneous tumor development and lung metastasis (b). The degree of STAT3 activation in the subcutaneous tumor tissues was evaluated using immunostaining (c). The number of CD4+ lymphocytes and CD8+ lymphocytes in the subcutaneous tumor tissues was evaluated using immunostaining (d). Inhibitory effects of corosolic acid on the MDSC-induced immunosuppressive activity in CD4 and CD8 T cells (e). MDSCs were isolated from tumor-bearing mice treated with or without corosolic acid, and the mRNA expression was examined using real-time PCR (f). The data are presented as the mean ± SD. * versus control.
