Resveratrol as a Therapeutic Agent for Alzheimer’s Disease

Table 1

Neuroprotective effects of resveratrol in vivo.

Animals	Administration	Effects	Reference
Tg2576 mice	Drinking Cabernet Sauvignon	Reduced amyloid neuropathology and attenuated spatial memory deterioration.	[30]
Tg2576 mice	Fed with GPSE	Reduced oligomerization of A peptide and attenuated cognitive impairments.	[32]
APP/PS1 mice	Diet with resveratrol	Reduced the number of activated microglia.	[17]
C67BL/6J mice	Diet with trans-resveratrol daily	Reduced serum TNF-α and enhanced cognitive function.	[33]
C57Bl/6 mice	Resveratrol in food	(1) Increased microvascular density and decreased number of vacuolar abnormalities. (2) Improved in spatial orientation and memory performance.	[10]
C57Bl/6J mice	Resveratrol in food	Increased mitochondrial function, improved aerobic capacity, and enhanced sensorimotor function.	[34]
2-month-old male mice	i.p. injection of resveratrol	Activated AMPK in the brain.	[35]
Wistar rats, ICV injection of STZ	ICV injection of resveratrol	Increased retention latencies and shorter transfer latencies.	[36]
Rats, ICV administration of colchicine	Chronically treated with resveratrol (p.o.)	MDA levels reduced but GSH and AchE activity recovered.	[37]
Wistar rats, i.p. injection of STZ	i.p. injection of resveratrol	Modulates cholinergic neurotransmission and consequently improves cognition.	[38]
Sprague-Dawley rat	Oral resveratrol	Resveratrol may have positive effects on the expression of BDNF.	[39]
Inducible p25 transgenic mice	ICV injection of resveratrol	Reduces neurodegeneration in hippocampus and prevents cognitive decline.	[40]