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BioMed Research International
Volume 2014 (2014), Article ID 351821, 13 pages
The Proteome of the Differentiating Mesencephalic Progenitor Cell Line CSM14.1 In Vitro
1Department of Anatomy, University of Rostock, Gertrudenstraße 9, 18057 Rostock, Germany
2Department of Pathology, University of Würzburg, Josef-Schneider Straße 2, 97080 Würzburg, Germany
3Proteome Center Rostock, University of Rostock, Schillingallee 69, 18055 Rostock, Germany
Received 5 July 2013; Accepted 16 December 2013; Published 30 January 2014
Academic Editor: Stephan M. Huber
Copyright © 2014 B. Weiss et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- O. Lindvall and Z. Kokaia, “Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease,” Trends in Pharmacological Sciences, vol. 30, no. 5, pp. 260–267, 2009.
- O. Lindvall and A. Björklund, “Cell therapeutics in parkinson's disease,” Neurotherapeutics, vol. 8, no. 4, pp. 539–548, 2011.
- U. Pfisterer, A. Kirkeby, O. Torper et al., “Direct conversion of human fibroblasts to dopaminergic neurons,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 25, pp. 10343–10348, 2011.
- A. Martínez-Serrano and A. Björklund, “Immortalized neural progenitor cells for CNS gene transfer and repair,” Trends in Neurosciences, vol. 20, no. 11, pp. 530–538, 1997.
- M. M. Durand, D. C. Chugani, M. Mahmoudi, and M. E. Phelps, “Characterization of neuron-like cell line immortalized from primary rat mesencephalon cultures,” Society for Neuroscience Abstracts, vol. 16, p. 40, 1990.
- L. T. Zhong, T. Sarafian, D. J. Kane et al., “bcl-2 inhibits death of central neural cells induced by multiple agents,” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 10, pp. 4533–4537, 1993.
- R. Anton, J. H. Kordower, N. T. Maidment et al., “Neural-targeted gene therapy for rodent and primate hemiparkinsonism,” Experimental Neurology, vol. 127, no. 2, pp. 207–218, 1994.
- R. Anton, J. H. Kordower, D. J. Kane, C. H. Markham, and D. E. Bredesen, “Neural transplantation of cells expressing the anti-apoptotic gene bcl-2,” Cell Transplantation, vol. 4, no. 1, pp. 49–54, 1995.
- S. J. P. Haas and A. Wree, “Dopaminergic differentiation of the Nurr1-expressing immortalized mesencephalic cell line CSM14.1 in vitro,” Journal of Anatomy, vol. 201, no. 1, pp. 61–69, 2002.
- S. J. P. Haas, S. Beckmann, S. Petrov, C. Andressen, A. Wree, and O. Schmitt, “Transplantation of immortalized mesencephalic progenitors (CSM14.1 cells) into the neonatal Parkinsonian rat caudate putamen,” Journal of Neuroscience Research, vol. 85, no. 4, pp. 778–786, 2007.
- R. Hoffrogge, S. Beyer, R. Hübner et al., “2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells,” Proteomics, vol. 7, no. 1, pp. 33–46, 2007.
- C. Winkler, R. A. Fricker, M. A. Gates et al., “Incorporation and glial differentiation of mouse EGF-responsive neural progenitor cells after transplantation into the embryonic rat brain,” Molecular and Cellular Neurosciences, vol. 11, no. 3, pp. 99–116, 1998.
- E. Cattaneo and L. Conti, “Generation and characterization of embryonic striatal conditionally immortalized ST14A cells,” Journal of Neuroscience Research, vol. 53, no. 2, pp. 223–234, 1998.
- H. J. G. Gundersen, “Estimators of the number of objects per area unbiased by edge effects,” Microscopica Acta, vol. 81, no. 2, pp. 107–117, 1978.
- G. Lessner, O. Schmitt, S. J. P. Haas et al., “Differential proteome of the striatum from hemiparkinsonian rats displays vivid structural remodeling processes,” Journal of Proteome Research, vol. 9, no. 9, pp. 4671–4687, 2010.
- P. S. Vernon and D. E. Griffin, “Characterization of an in vitro model of alphavirus infection of immature and mature neurons,” Journal of Virology, vol. 79, no. 6, pp. 3438–3447, 2005.
- L. F. Eng, R. S. Ghirnikar, and Y. L. Lee, “Glial Fibrillary Acidic Protein: GFAP-thirty-one years (1969–2000),” Neurochemical Research, vol. 25, no. 9-10, pp. 1439–1451, 2000.
- C. N. Svendsen, A. Bhattacharyya, and Y. T. Tai, “Neurons from stem cells: preventing an identity crisis,” Nature Reviews Neuroscience, vol. 2, no. 11, pp. 831–834, 2001.
- J. M. Polak and S. van Noorden, An Introduction to Immunocytochemistry: Current Techniques and Problems, Oxford University Press, Oxford, UK, 1992.
- P. Kermer, M. Krajewska, J. M. Zapata et al., “Bag1 is a regulator and marker of neuronal differentiation,” Cell Death and Differentiation, vol. 9, no. 4, pp. 405–413, 2002.
- S. J.-P. Haas, S. Petrov, G. Kronenberg, O. Schmitt, and A. Wree, “Orthotopic transplantation of immortalized mesencephalic progenitors (CSM14.1 cells) into the substantia nigra of hemiparkinsonian rats induces neuronal differentiation and motoric improvement,” Journal of Anatomy, vol. 212, no. 1, pp. 19–30, 2008.
- S. Udenfriend and J. B. Wyngaarden, “Precursors of adrenal epinephrine and norepinephrine in vivo,” Biochimica et Biophysica Acta, vol. 20, no. 1, pp. 48–52, 1956.
- E. Y. Levin, B. Levenberg, and S. Kaufman, “The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine,” The Journal of Biological Chemistry, vol. 235, pp. 2080–2086, 1960.
- P. McCaffery and U. C. Drager, “High levels of a retinoic acid-generating dehydrogenase in the meso- telencephalic dopamine system,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 16, pp. 7772–7776, 1994.
- N. S. K. Haque, C. J. Leblanc, and O. Isacson, “Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons,” Cell Transplantation, vol. 6, no. 3, pp. 239–248, 1997.
- Å. Wallén, R. H. Zetterström, L. Solomin, M. Arvidsson, L. Olson, and T. Perlmann, “Fate of mesencephalic AHD2-expressing dopamine progenitor cells in Nurr1 mutant mice,” Experimental Cell Research, vol. 253, no. 2, pp. 737–746, 1999.
- C. P. M. Reutelingsperger, G. Hornstra, and H. C. Hemker, “Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord,” European Journal of Biochemistry, vol. 151, no. 3, pp. 625–629, 1985.
- R. J. Flower and N. J. Rothwell, “Lipocortin-1: cellular mechanisms and clinical relevance,” Trends in Pharmacological Sciences, vol. 15, no. 3, pp. 71–76, 1994.
- M. Perretti, “Lipocortin-derived peptides,” Biochemical Pharmacology, vol. 47, no. 6, pp. 931–938, 1994.
- P. Raynal and H. B. Pollard, “Annexins: the problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins,” Biochimica et Biophysica Acta, vol. 1197, no. 1, pp. 63–93, 1994.
- J. V. Bonventre, “Roles of phospholipases A2 in brain cell and tissue injury associated with ischemia and excitotoxicity,” Journal of Lipid Mediators and Cell Signalling, vol. 17, no. 1, pp. 71–79, 1997.
- J. Klein, “Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids,” Journal of Neural Transmission, vol. 107, no. 8-9, pp. 1027–1063, 2000.
- W. L. Titsworth, N. K. Liu, and X. M. Xu, “Role of secretory phospholipase A2 in CNS inflammation: implications in traumatic spinal cord injury,” CNS and Neurological Disorders, vol. 7, no. 3, pp. 254–269, 2008.
- G. S. D. Moses, M. D. Jensen, L. F. Lue et al., “Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease,” Journal of Neuroinflammation, vol. 3, p. 28, 2006.
- S. Marusic, M. W. Leach, J. W. Pelker et al., “Cytosolic phospholipase A2α-deficient mice are resistant to experimental autoimmune encephalomyelitis,” Journal of Experimental Medicine, vol. 202, no. 6, pp. 841–851, 2005.
- F. Pinto, T. Brenner, P. Dan, M. Krimsky, and S. Yedgar, “Extracellular phospholipase A2 inhibitors suppress central nervous system inflammation,” Glia, vol. 44, no. 3, pp. 275–282, 2003.
- T. Hayakawa, M. C. J. Chang, S. I. Rapoport, and N. M. Appel, “Selective dopamine receptor stimulation differentially affects [3H]arachidonic acid incorporation, a surrogate marker for phospholipase A2-mediated neurotransmitter signal transduction, in a rodent model of Parkinson's disease,” Journal of Pharmacology and Experimental Therapeutics, vol. 296, no. 3, pp. 1074–1084, 2001.
- M. Tariq, H. A. Khan, K. A. Moutaery, and S. A. Deeb, “Protective effect of quinacrine on striatal dopamine levels in 6-OHDA and MPTP models of Parkinsonism in rodents,” Brain Research Bulletin, vol. 54, no. 1, pp. 77–82, 2001.
- N. Liu, S. Han, P. H. Lu, and X. M. Xu, “Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats,” Journal of Neuroscience Research, vol. 77, no. 3, pp. 391–401, 2004.
- C. P. M. Reutelingsperger and W. L. van Heerde, “Annexin V, the regulator of phosphatidylserine-catalyzed inflammation and coagulation during apoptosis,” Cellular and Molecular Life Sciences, vol. 53, no. 6, pp. 527–532, 1997.
- V. A. Fadok, D. R. Voelker, P. A. Campbell, J. J. Cohen, D. L. Bratton, and P. M. Henson, “Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages,” The Journal of Immunology, vol. 148, no. 7, pp. 2207–2216, 1992.
- M. Leist and M. Jäättelä, “Four deaths and a funeral: from caspases to alternative mechanisms,” Nature Reviews Molecular Cell Biology, vol. 2, no. 8, pp. 589–598, 2001.
- R. F. A. Zwaal and A. J. Schroit, “Pathophysiologic implications of membrane phospholipid asymmetry in blood cells,” Blood, vol. 89, no. 4, pp. 1121–1132, 1997.
- N. Takei, K. Ohsawa, Y. Imaia, H. Nakao, A. Iwasaki, and S. Kohsaka, “Neurotrophic effects of annexin V on cultured neurons from embryonic rat brain,” Neuroscience Letters, vol. 171, no. 1-2, pp. 59–62, 1994.
- H. Mizuno, K. Asai, K. Fujita et al., “Neurotrophic action of lipocortin 1 derived from astrocytes on cultured rat cortical neurons,” Molecular Brain Research, vol. 60, no. 1, pp. 28–39, 1998.
- S. Han, K.-H. Zhang, P. H. Lu, and X. M. Xu, “Effects of annexins II and V on survival of neurons and astrocytes in vitro,” Acta Pharmacologica Sinica, vol. 25, no. 5, pp. 602–610, 2004.
- S. Hatano and F. Oosawa, “Isolation and characterization of plasmodium actin,” Biochimica et Biophysica Acta, vol. 127, no. 2, pp. 488–498, 1966.
- K. C. Holmes, D. Popp, W. Gebhard, and W. Kabsch, “Atomic model of the actin filament,” Nature, vol. 347, no. 6288, pp. 44–49, 1990.
- H. L. Yin and T. P. Stossel, “Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein,” Nature, vol. 281, no. 5732, pp. 583–586, 1979.
- H. L. Yin, J. H. Hartwig, K. Maruyama, and T. P. Stossel, “Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization,” Journal of Biological Chemistry, vol. 256, no. 18, pp. 9693–9697, 1981.
- J. A. Lamb, P. G. Allen, B. Y. Tuan, and P. A. Janmey, “Modulation of gelsolin function. Activation at low pH overrides Ca2+ requirement,” Journal of Biological Chemistry, vol. 268, no. 12, pp. 8999–9004, 1993.
- R. C. Robinson, M. Mejillano, V. P. Le, L. D. Burtnick, H. L. Yin, and S. Choe, “Domain movement in gelsolin: a calcium-activated switch,” Science, vol. 286, no. 5446, pp. 1939–1942, 1999.
- L. D. Burtnick, D. Urosev, E. Irobi, K. Narayan, and R. C. Robinson, “Structure of the N-terminal half of gelsolin bound to actin: roles in severing, apoptosis and FAF,” The EMBO Journal, vol. 23, no. 14, pp. 2713–2722, 2004.
- P. A. Jammey, K. Iida, H. L. Yin, and T. P. Stossel, “Polyphosphoinositide micelles and polyphosphoinositide-containing vesicles dissociate endogenous gelsolin-actin complexes and promote actin assembly from the fast-growing end of actin filaments blocked by gelsolin,” Journal of Biological Chemistry, vol. 262, no. 25, pp. 12228–12236, 1987.
- P. A. Janmey and T. P. Stossel, “Modulation of gelsolin function by phosphatidylinositol 4,5 bisphosphate,” Nature, vol. 325, no. 6102, pp. 362–364, 1987.
- E. J. Furnish, W. Zhou, C. C. Cunningham, J. A. Kas, and C. E. Schmidt, “Gelsolin overexpression enhances neurite outgrowth in PC12 cells,” The FEBS Letters, vol. 508, no. 2, pp. 282–286, 2001.
- E. N. Star, D. J. Kwiatkowski, and V. N. Murthy, “Rapid turnover of actin in dendritic spines and its regulation by activity,” Nature Neuroscience, vol. 5, no. 3, pp. 239–246, 2002.
- J. H. Dong, G. X. Ying, X. Liu et al., “Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation,” Hippocampus, vol. 16, no. 1, pp. 91–100, 2006.
- R. D. Mullins, J. A. Heuser, and T. D. Pollard, “The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 11, pp. 6181–6186, 1998.
- W. T. Lankes and H. Furthmayr, “Moesin: a member of the protein 4.1-talin-ezrin family of proteins,” Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 19, pp. 8297–8301, 1991.
- P. Mangeat, C. Roy, and M. Martin, “ERM proteins in cell adhesion and membrane dynamics,” Trends in Cell Biology, vol. 9, no. 5, pp. 187–192, 1999.
- A. Bretscher, K. Edwards, and R. G. Fehon, “ERM proteins and merlin: integrators at the cell cortex,” Nature Reviews Molecular Cell Biology, vol. 3, no. 8, pp. 586–599, 2002.
- M. Algrain, O. Turunen, A. Vaheri, D. Louvard, and M. Arpin, “Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker,” Journal of Cell Biology, vol. 120, no. 1, pp. 129–140, 1993.
- O. Turunen, T. Wahlström, and A. Vaheri, “Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family,” Journal of Cell Biology, vol. 126, no. 6, pp. 1445–1453, 1994.
- M. D. Henry, C. G. Agosti, and F. Solomon, “Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains,” Journal of Cell Biology, vol. 129, no. 4, pp. 1007–1022, 1995.
- K. Pestonjamasp, M. R. Amieva, C. P. Strassel, W. M. Nauseef, H. Furthmayr, and E. J. Luna, “Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes,” Molecular Biology of the Cell, vol. 6, no. 3, pp. 247–259, 1995.
- A. H. Chishti, A. C. Kim, S. M. Marfatia et al., “The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane,” Trends in Biochemical Sciences, vol. 23, no. 8, pp. 281–282, 1998.
- M. Hirao, N. Sato, T. Kondo et al., “Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and rho-dependent signaling pathway,” Journal of Cell Biology, vol. 135, no. 1, pp. 37–51, 1996.
- T. Matsui, M. Maeda, Y. Doi et al., “Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association,” Journal of Cell Biology, vol. 140, no. 3, pp. 647–657, 1998.
- A. Zimprich, S. Biskup, P. Leitner et al., “Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology,” Neuron, vol. 44, no. 4, pp. 601–607, 2004.
- C. Paisán-Ruíz, S. Jain, E. W. Evans et al., “Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease,” Neuron, vol. 44, no. 4, pp. 595–600, 2004.
- D. MacLeod, J. Dowman, R. Hammond, T. Leete, K. Inoue, and A. Abeliovich, “The familial parkinsonism gene LRRK2 regulates neurite process morphology,” Neuron, vol. 52, no. 4, pp. 587–593, 2006.
- F. Bradke and C. G. Dotti, “The role of local actin instability in axon formation,” Science, vol. 283, no. 5409, pp. 1931–1934, 1999.
- F. Bradke and C. G. Dotti, “Changes in membrane trafficking and actin dynamics during axon formation in cultured hippocampal neurons,” Microscopy Research and Technique, vol. 48, no. 1, pp. 3–11, 2000.