BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage

<table>GFP+ HNPCs injected to the internal auditory meatus with application of PA gel only (Group 1). Immunohistochemical staining was performed with DAPI ((b), (f)) for cell nuclei, GFP ((c), (g)) for transplanted cells, and TUJ1 ((d), (h)) to verify differentiation. At three weeks following transplantation, GFP positive cells were identified along the auditory nerve “i” and in the brain stem “e.” Only a few cells have differentiated as verified by yellow double staining (GFP and TUJ1; (a), (c), (d), (e), (g), (h), and (i)). White arrowheads indicating surviving GFP+ HNPCs in the auditory nerve “i” and in the BS “e.” AN: auditory nerve; BS: brain stem; C: cochlea. Scale bar (a) 400 <i>μ</i>m, (b–i) 100 <i>μ</i>m.</table>

BioMed Research International

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Figure 2: BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage 

Figure 2 | BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage 