BDNF Increases Survival and Neuronal Differentiation of Human Neural Precursor Cells Cotransplanted with a Nanofiber Gel to the Auditory Nerve in a Rat Model of Neuronal Damage
Figure 5
Graphs illustrating the quantification of numbers of GFP+ HNPCs, differentiated cells, and cells with neuronal outgrowths. (a) Total number of GFP+ HNPCs. Groups 2 and 3 had significantly better cell survival compared to Group 1 (). After 3 weeks the majority of the surviving cells were observed in the AN whereas after 6 weeks the majority of the cells were found in the BS. No cells were found in Group 4 (data not shown). (b) Number of double-labeled (GFP and TUJ1) differentiated cells. Groups 2 and 3 had significantly more differentiated cells than Group 1 (). After six weeks, the majority of the differentiated cells were found in the BS. (c) Number of differentiated cells with outgrowth of fibers. Groups 2 and 3 had significantly more cells with fiber outgrowth as compared to Group 1 ().
