Premedication with Oral Alprazolam and Melatonin Combination: A Comparison with Either Alone—A Randomized Controlled Factorial Trial

Table 1

Patient data and perioperative variables. Values are expressed as number (%), mean ± SD or median (interquartile range) as applicable. No significant differences.

	Melatonin and; Alprazolam	Alprazolam	Melatonin	Placebo
Patients data
Number of patients (𝑛)	20	20	20	20
Gender (male/female)	6/14	4/16	4/16	5/15
Age (yr)	38±14	37±10	34±11	36±13
Weight (kg)	52±7	52±7	57±11	57±12
History of previous surgery (𝑛)	11 (55)	8 (40)	8 (40)	9 (45)
VAS baseline (cm)	5 (3.6–6)	5 (4.2–7)	5 (4–6)	5 (4–6)
Perioperative variables
Number of patients (𝑛)	19	18	20	18
Propofol (mg) consumed until
Loss of verbal command	66±21	59±21	79.2±4	75.8±25
Loss of eyelash reflex	73±22	62±22	79±35	80.8±29
Anesthesia time (min)	77±34	73±21	66±18	72±18
Patients (𝑛) with
Nausea and vomiting	8 (42)	6 (33)	7 (35)	9 (50)
Headache	4 (21)	3 (17)	4 (20)	5 (28)
Dizziness	3 (16)	2 (11)	5 (25)	4 (22)
Restlessness	7 (37)	9 (50)	6 (30)	8 (44)