Clinical Study
Premedication with Oral Alprazolam and Melatonin Combination: A Comparison with Either Alone—A Randomized Controlled Factorial Trial
Table 2
Showing sedation in the four groups at various time points after premedication. Values are expressed as number of patients (%).
| | | Melatonin and Alprazolam
() | Alprazolam
() | Melatonin
() | Placebo
() |
| | Baseline | | | | | | Alert | 18 (90) | 20 (100) | 17 (85) | 20 (100) | | Arouses to voice | 2 (10) | 0 (0) | 3 (15) | 0 (0) | | 15 min after premedication | | | | | | Alert | 13 (65) | 16 (80) | 13 (65) | 18 (90) | | Arouses to voice | 4 (20) | 4 (20) | 6 (30) | 2 (10) | | Arouses with gentle tactile stimulation | 3 (15) | 0 (0) | 1 (5) | 0 (0) | | 30 min after premedication | | | | | | Alert | 7 (35) | 10 (50) | 9 (45) | 15 (75) | | Arouses to voice | 8 (40) | 6 (30) | 8 (40) | 4 (20) | | Arouses with gentle tactile stimulation | 4 (20) | 4 (20) | 3 (15) | 1 (5) | | Arouses with vigorous tactile stimulation | 1 (5) | 0 (0) | 0 (0) | 0 (0) | | 60 min after premedication | | | | | | Alert | 3 (15) | 6 (30) | 10 (50) | 12 (60) | | Arouses to voice | 8 (40) | 9 (45) | 7 (35) | 8 (40) | | Arouses with gentle tactile stimulation | 4 (20) | 4 (20) | 3 (15) | 0 (0) | | Arouses with vigorous tactile stimulation | 5 (25) | 1 (5) | 0 (0) | 0 (0) |
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