Premedication with Oral Alprazolam and Melatonin Combination: A Comparison with Either Alone—A Randomized Controlled Factorial Trial

Table 3

Showing the result of assessment of memory for the five pictures shown at various time points related to premedication on the previous day and the two events. Values are expressed as number of patients (%).

	Melatonin and Alprazolam; (𝑛=19)	Alprazolam; (𝑛=18)	Melatonin; (𝑛=20)	Placebo; (𝑛=18)	𝑃 value
Picture 1 (shown 10 min prior to premedication)
Recalled	15 (79)	17 ((94)	15 (75)	14 (78)	0.178
Recognized	19 (100)	18 (100)	20 (100)	18 (100)
Picture 2 (shown just prior to premedication)
Recalled	15 (79)	14 (78)	13 (65)	15 (83)	0.965
Recognized	19 (100)	18 (100)	20 (100)	18 (100)
Picture 3 (shown 15 min after premedication)
Recalled	15 (79)	17 (94)	13 (65)	13 (72)	0.051
Recognized	17 (89)	18 (100)	20 (100)	18 (100)
Picture 4 (shown 30 min after premedication)
Recalled	9 (47)	8 (44)	10 (50)	14 (78)	0.255
Recognized	16 (84)	15 (83)	19 (95)	18 (100)
Picture 5 (shown 60 min after premedication)
Recalled	4 (21)	5 (28)	13 (65)	14 (78)	0.003
Recognized	10 (53)	9 (50)	18 (90)	16 (89)
Event 1 (transfer to operating room)
Recalled	14 (74)	14 (78)	19 (95)	18 (100)	0.047
Event 2 (intravenous cannulation)
Recalled	12 (63)	14 (78)	18 (90)	16 (89)	0.135