Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat

Table 1

Methacholine concentration-response curve characteristics. Nonlinear analyses according to bell-shaped response-curves.

Treatment	𝑛H (first part of biphasic curve)	logEC50	𝑅^2	Curve differences (𝐹, 𝑃)
Saline-saline	0.74	−4.80	0.71	4.38, 0.001
Saline-CYP	0.89	−5.43	0.75
4-DAMP-saline	0.75	−4.13	0.85	7.26, <0.0001
4-DAMP-CYP	0.89	−5.25	0.64
L-NAME-saline	0.91	−5.00	0.79	2.55, 0.035
L-NAME-CYP	0.97	−5.41	0.83