Differential Gene Expression in High- and Low-Active Inbred Mice

Table 2

Gene expression ratios.

	Gene	Tissue	Expression ratio (AU)		𝑃 value
			C57L/J (high-active)	C3H/HeJ (low-active)
Wheel exposed	Actn2	sol	1.1±0.32	0.95±0.22	0.55
	Casq1	sol	0.85±0.04	1.17±0.04	0.0003*
	Glut4	sol	0.94±0.07	1.08±0.13	0.2
	Lepr	sol	1.0±0.27	1.05±0.26	0.85
	Mstn	sol	0.59±0.05	1.7±0.14	0.002*
	Actn2	NA	0.14±0.12	0.44±0.53	0.13
	Casq1	NA	0.16±0.14	0.12±0.05	0.64
	Glut4	NA	0.17±0.10	0.2±.07	0.58
	Lepr	NA	1.77±2.47	1.33±0.73	0.72
	Mstn	NA	0.12±0.07	0.22±0.22	0.37
Naïve	Actn2	sol	1.27±0.96	1.33±1.1	0.58
	Actn3	sol	1.25±0.94	1.35±1.57	0.58
	Casq1	sol	1.05±0.54	0.79±0.40	0.4
	Glut4	sol	1.22±0.56	0.89±0.19	0.22
	Lepr	sol	0.94±0.66	1.03±0.40	0.82
	Mstn	sol	0.98±0.58	1.38±0.55	0.27
	Drd2	NA	1.69±0.85	0.80±0.47	0.06
	Lepr	NA	0.35±0.09	0.26±0.10	0.18
	Mc4r	NA	0.88±0.19	1.21±0.36	0.08
	Papss2	NA	1.17±0.33	0.97±0.48	0.4

Gene expression ratio was calculated from Pfaffl [36]. Values are described as mean ± SD; “sol” indicates soleus; “NA” nucleus accumbens. *Indicates differential expression of gene between strains.