Research Article

Differential Protein Network Analysis of the Immune Cell Lineage

Table 2

Lineage specific protein network exemplars.

Exemplar ID Genes assigned to the protein network exemplar Functional annotation value Immune cell type

102EPOR, PTPN1, STAT5BJak-STAT signaling pathway (KEGG)Hematopoetic stem cells

20CCNT1, EIF2B1, MYCHematopoetic stem cells

86EZR, NGFRAP1, NTF3Neurotrophin signaling pathwayGranylocytes

49GRB7, TIA1Hematopoetic stem cells

104ARRB1 BGN PTSMacrophages

96PLCB2, POLA1, VIMGranylocytes

98POT1A, TERF1Telomere maintenance via telomerase (GO-BP)Hematopoetic stem cells

7AR, ATRX, CTCF, SMC1A, SMC3 Cell cycle (KEGG)Dendritic cells

119CRE, PRPF40A, SMC2Nucleoplasm (GO-CC)Dendritic cells

61CLDN11, CNOT6L, ITGA5, ITGB1, SPARCCell adhesion molecules (CAMs) (KEGG)Macrophage

10BICC1, CREBBP, CSK, KHDRBS1, PRMT1, RBM39Control of Gene Expression by Vitamin D Receptor (KEGG)Ggranylocyte

97EIF3L, POLR1B, POLR1ERNA polymerase (KEGG)Hematopoetic stem cells

41 BRCA2, CEBPD, FANCD2Cell cycle process (GO-BP)Macrophages

70ADRB2, DLL1, MAGI3Plasma membrane (GO-CC)abTcells

88CHORDC1, IGBP1, NR3C1, PPP5CTransition metal Ion binding (GO-MF)Hematopoetic stem cells

75MEOX1, MEOX2, TLE4Transcription factor activityGranylocytes

42 FBXW7, NOTCH1, NPM1 STAT4 Notch signaling pathwayHematopoetic stem cells

36AEBP2, EED, MORC3, SETX, UHRF1Nucleoplasm (GO-CC)Dendritic cells

38EIF3A, EIF3B, EIF3I, EIF4E Translational initiation (GO-BP)Hematopoetic stem cells