Nodal Promotes the Self-Renewal of Human Colon Cancer Stem Cells via an Autocrine Manner through Smad2/3 Signaling Pathway
Figure 3
Expression of NODAL ligand and its receptor ALK-4 in human colon cancer tissues and noncancerous colon tissues. (a–d) Immunohistochemistry revealed the expression of NODAL in human colon cancer tissues (a) and adjacent noncancerous colon tissues (b) and ALK-4 in human colon cancer tissues (c) and adjacent noncancerous colon tissues (d), as well as Nodal and its receptor ALK-4 in human colon cancer tissues (e). Scale bars in (a)–(e) = 10 μm.
