Deregulation of Serum MicroRNA Expression Is Associated with Cigarette Smoking and Lung Cancer

Table 3

Prediction of the target genes of let-7i-3p and miR-154-5p and their pathways.

miRNA	Target gene	Signaling pathway
let-7i-3	ACTB	Phagosome, Hippo signaling pathways
	ADHFE1	Hippo signaling pathway
	ATP2A2	Calcium signaling pathway
	BDNF	MAPK signaling pathway
	BTG3	RNA degradation
	EMP2	VEGF signaling pathway
	DLX5	IRS-2-AKT signaling pathway
	CXCR6	Chemokine signaling pathway
	CXCL12	Chemokine signaling pathway, NF-B signaling pathway
	HES1	Notch signaling pathway
	RASSF3	Pathways in cancer, NSCLC
	SIX1	Transcriptional misregulation in cancer
miR-154-5p*	ABCC9	ABC transporters
	ROS	Transcriptional misregulation in cancers, ErbB signaling pathway, focal adhesion, NF-B signaling pathways
	ATG7	Cellular processes, regulation of autophagy
	TNFAIP3	NF-B signaling pathway, NOD-like receptor signaling pathway
	CUL2	HIF-1 signaling pathway, pathways in cancer

Target gene prediction implied that the main target genes of let-7i-3p are ADHFE1, ACTB, ATP2A2, and so forth, which play roles in the occurrence, development, and metastasis of lung cells during carcinogenesis through the NF-B, MAPK, and Notch signaling pathways.
*Target gene prediction implied that the main target genes of miR-154-5p are ABCC9, ROS, ATG7, and so forth, which play roles in the occurrence, development, and metastasis of lung cells during carcinogenesis through the NF-B, HIF-1, MAPK, and autophagy signaling pathways.