BioMed Research International

Research Article

Extracellular Matrix Proteins Expression Profiling in Chemoresistant Variants of the A2780 Ovarian Cancer Cell Line

Table 1

The gene list showing the fold-change in extracellular matrix related proteins in the drug-resistant sublines with respect to the parental A2780 cell line.


Gene symbol	RefSeQ transcript ID	Fold-change
Gene symbol	RefSeQ transcript ID	C versus P1	C versus P2	C versus C1	C versus C2	C versus D1	C versus D2	C versus T1	C versus T2

ITGB8	NM_002214	NS	NS	NS	NS	NS	NS	19.97	5.35
COL1A2	NM_000089	5.54	NS	NS	NS	NS	NS	56.50	66.36
COL4A1	NM_001845	NS	8.05	NS	NS	NS	NS	NS	NS
COL11A1	NM_001854	−29.34	−149.24	−106.43	−56.2398	−81.08	NS	−57.68	−24.29
COL12A1	NM_004370	NS	NS	23.92	NS	16.35	NS	NS	NS
COL15A1	NM_001855	NS	NS	NS	NS	NS	NS	NS	10.17
COL16A1	NM_001856	8.85	NS	NS	NS	NS	NS	NS	NS
COL17A1	NM_000494	16.79	NS	NS	NS	NS	NS	NS	NS
COL18A1	NM_030582	5.90	NS	NS	NS	NS	NS	NS	NS
COL21A1	NM_030820	55.13	NS	NS	NS	NS	NS	NS	NS
LOX	NM_002317	35.03	NS	NS	NS	NS	NS	NS	NS
SPARC	NM_003118	NS	NS	NS	NS	NS	NS	NS	17.71
TGFBI	NM_000358	NS	NS	NS	NS	NS	NS	27.94	17.48
LAMA1	NM_005559	−18.76	NS	NS	NS	NS	NS	NS	NS
LAMA2	NM_000426	NS	NS	NS	−33.4055	NS	NS	NS	NS
LAMA4	NM_001105206	NS	NS	NS	NS	NS	NS	9.52	8.92
LAMB1	NM_002291	15.89	93.16	NS	NS	8.65	NS	NS	NS
LAMB3	NM_000228	8.24	NS	NS	NS	NS	NS	NS	NS
FN1	NM_002026	−5.27	−5.049	NS	NS	NS	NS	NS	NS
FLRT2	NM_013231	NS	NS	6.37	NS	NS	NS	NS	NS
FBN1	NM_000138	NS	NS	−9.21	−13.3875	NS	NS	NS	NS
EFEMP1	NM_001039348	NS	NS	NS	NS	35.33	NS	NS	NS
GPC3	NM_004484	NS	NS	NS	NS	NS	NS	NS	23.71
GPC4	NM_001448	NS	NS	NS	NS	NS	NS	NS	19.80
GPC6	NM_005708	−33.30	NS	NS	NS	NS	NS	−16.01	NS
DCN	NM_001920	Ns	−10.52	NS	NS	NS	NS	NS	NS
EPYC	NM_004950	NS	NS	NS	NS	8.52	13.7955	NS	NS
KERA	NM_007035	−10.79	−7.94	−9.65	−6.08735	NS	NS	NS	NS
LUM	NM_002345	NS	−48.58	NS	NS	NS	NS	NS	NS
HAPLN1	NM_001884	−8.73	NS	10.65	NS	NS	9.29074	5.21	9.46
SDC2	NM_002998	NS	22.54	13.29	NS	19.13	NS	NS	NS
KRT8	NM_002273	NS	NS	NS	NS	NS	NS	NS	8.12
MGP	NM_000900	62.13	NS	NS	6.21346	9.13	NS	82.90	241.13

NS: up- or downregulation between 5 and −5, indicative of changes in expressions that are not statistically significant.