The Structural Modeling of the Interaction between Levofloxacin and the Mycobacterium tuberculosis Gyrase Catalytic Site Sheds Light on the Mechanisms of Fluoroquinolones Resistant Tuberculosis in Colombian Clinical Isolates

Table 2

QRDR-A and QRDR-B mutations spectrum for the 10 FQ resistant MTB isolates.

Isolates	SNP	Amino acid change	Codon	Susceptibility to FQ
				OFX	LVX	MFX
TBR-67*	GAC/GGC	Asp/Gly	94	R	R	R
TBR102*(XDR)	GAC/GGC	Asp/Gly	94	R	R	R
TBR-49*	GCG/GTG	Ala/Val	90	R	R	S
TBR-111*(XDR)	GAC/GGC	Asp/Gly	94	R	R	R
TBR-31*	GCG/GTG	Ala/Val	90	R	R	S
TBR-176*(XDR)	GAC/GGC	Asp/Gly	94	R	R	R
TBR-73*	No mutation			R	R	R
TBR-18*(XDR)	No mutation			R	S	S
TBR-107*(XDR)	No mutation			R	S	S
TBR-103*(XDR)	No mutation			R	R	R

∗Isolates with Ser95Thr mutation.
R: resistant isolate; S: susceptible isolate.