Nerve Regenerative Effects of GABA-B Ligands in a Model of Neuropathic Pain

Table 2

Footprint analysis of most important parameters of locomotor activity in sham, PSL, and PSL-treated rats.

Distance; 1–5 toe

Distance; 2–4 toe

Length; foot step

Stride width

Stride length

Area touched

Sham

1.95

±0.03

1.06

±0.03

3.21

±0.09

3.64

±0.06

11.46

±0.49

1.79

±0.08

PSL

0.76

±0.04

0.50

±0.03

4.39

±0.13

4.59

±0.11

13.32

±0.54

1.90

±0.17

𝑃=0.000116

𝑃=0.000131

𝑃=0.000116

𝑃=0.000119

𝑃=0.404063

𝑃=0.968606

PSL + baclofen

0.70

±0.05

0.35

±0.03

4.10

±0.18

3.85

±0.15

9.60

±0.71

1.06

±0.14

𝑃=0.921960

𝑃=0.547398

𝑃=0.648819

𝑃=0.002619

𝑃=0.018476

𝑃=0.000914

PSL + CGP56433

1.42

±0.05

0.86

±0.03

2.61

±0.12

3.28

±0.11

9.29

±0.64

1.13

±0.20

𝑃=0.000116

𝑃=0.000135

𝑃=0.000113

𝑃=0.000117

𝑃=0.018430

𝑃=0.005125

PSL + baclofen + CGP56433

1.58

±0.09

0.98

±0.04

3.51

±0.12

3.63

±0.15

10.16

±0.93

1.51

±0.11

𝑃=0.000116

𝑃=0.000131

𝑃=0.000466

𝑃=0.000129

𝑃=0.056044

𝑃=0.289398

Data are expressed as mean (in cm) ± SEM. Statistic with one-way Anova and Tuckey’s post hoc test. Significance for PSL was calculated versus sham-operated, while significance for baclofen, CGP56433, and baclofen/CGP56433 groups was calculated versus PSL.