Polymorphisms at Amino Acid Residues 141 and 154 Influence Conformational Variation in Ovine PrP

Figure 1

Location of clusters of high sequence conservation within the ovine PrP molecule. Sequence conservation scores for all the amino acids in PrP were mapped on the crystal structure of ALRQ ovine PrP and neighbouring residue scores contoured. The blue colouration highlights those areas with the greatest degree of sequence conservation.