Lentiviral Protein Transduction with Genome-Modifying HIV-1 Integrase-I-PpoI Fusion Proteins: Studies on Specificity and Cytotoxicity

Figure 5

Development of tumour volumes following LVV transduction. Volume changes (mean ± SD) of subcutaneous A549 tumours treated with wild-type control vector (wt IN), active endonuclease containing vector (IN-I-PpoI, I-PpoI in short), or thymidine kinase transgene-containing vector (wt IN+TK) are shown. Group sizes were LVV IN_wt, 𝑛=17; LVV IN-I-PpoI, 𝑛=18; and LVV IN_wt TK, 𝑛=6. Differences between groups were analyzed by two-way ANOVA and Tukey’s multiple comparisons test. ^∗∗∗𝑃<0.001; ^∗∗𝑃=0.001 to 𝑃<0.01; ^∗𝑃=0.01 to 𝑃<0.05.