Evaluation of Azathioprine-Induced Cytotoxicity in an In Vitro Rat Hepatocyte System

Figure 3

Proposed routes of AZA-induced cytotoxicity in isolated rat hepatocytes. XO, xanthine oxidase; GST, glutathione S-transferase; NAC, N-acetylcysteine; HGPRT, hypoxanthine guanine phosphoribosyl transferase; TPMT, thiopurine S-methyl transferase.