MicroRNA Era: The Importance for Diagnosis and Prognosis of Adrenocortical Tumors

Table 1

Summary of the current studies that evaluated microRNAs expression profiles in adrenocortical tumors.

Study	Tumors	Dysregulated microRNAs	Major findings
Tömböl et al., 2009 [47]	8 ACAs/4 ACCs/4 normal cortices	miR-184, miR-210, miR-503; miR-214, miR-511	Difference between dCTmiR-511 and dCTmiR-511 was able to differentiate adenomas from carcinomas
Soon et al., 2009 [48]	27 ACAs/22 ACCs/6 normal cortices	miR-195, miR-335, miR-7	High levels of miR-483-5p and low levels of miR-195 predicted worst overall survival
Patterson et al., 2011 [50]	26 ACAs/10 ACCs/21 normal cortices	miR-483-5p; miR-195, miR-125b, miR-100	Overexpression of miR-483-5p was able to diagnose carcinomas. The miR-483-5p and IGF2 were coexpressed
Özata et al., 2011 [52]	26 ACAs/22 ACCs/10 normal cortices	miR-483-3p, miR-483-5p, miR-210, miR-21; miR-1974, miR-195, miR-497	Downregulation of miR-483-3p and overexpression of miR-195 or miR-497 led to induction cell death in vitro
Chabre et al., 2013 [53]	16 ACAs/30 ACCs	miR-483-5p; miR-195, miR-335	High circulation levels of miR-483-5p or low levels of miR-195 were associated with worst recurrence-free and overall survival

ACAs: adrenocortical adenomas; ACCs: adrenocortical carcinomas; miRNAs in bold are overexpressed and regular ones are underexpressed in carcinomas comparing to adenomas.