No/minimal residual effect at surgery (4-5 drug half-lives) CrCl > 50 mL/min: 3 days CrCl 30–50 mL/min: 4 to 5 days Mild-moderate effect at surgery (2-3 drug half-lives) CrCl > 50 mL/min: 2 days CrCl 30–50 mL/min: 3 days
No/minimal residual effect at surgery (4-5 drug half-lives) CrCl > 50 mL/min: 3 days CrCl 30–50 mL/min: 4 to 5 days Mild-moderate effect at surgery (2-3 drug half-lives) CrCl > 50 mL/min: 2 days CrCl 30–50 mL/min: 3 days
No/minimal residual effect at surgery (4-5 drug half-lives) CrCl > 50 mL/min: 3 days CrCl 30–50mL/min: 4 to 5 days Mild-moderate effect at surgery (2-3 drug half-lives) CrCl > 50 mL/min: 2 days CrCl 30–50 mL/min: 3 days
CrCl > 50 mL/min: Low risk bleeding surgery°: last dose 2 days before surgery High risk bleeding surgery: Last dose 3 days before surgery CrCl 30–50 mL/min: Low risk bleeding surgery°: Last dose 3 days before surgery High risk bleeding surgery: Last dose 4-5 days before surgery
CrCl > 30 mL/min: Low risk bleeding surgery°: last dose 2 days before surgery High risk bleeding surgery: Last dose 3 days before surgery CrCl 15–29.9 mL/min: Low risk bleeding surgery°: Last dose 3 days before surgery High risk bleeding surgery: Last dose 4 days before surgery
CrCl > 50 mL/min: Low risk bleeding surgery°: last dose 2 days before surgery High risk bleeding surgery: Last dose 3 days before surgery CrCl 30–50 mL/min: Low risk bleeding surgery°: Last dose 3 days before surgery High risk bleeding surgery: Last dose 4 days before surgery
Low risk procedure1: 1 day Other procedures than low risk bleeding procedures2: stop 5 days before surgery/invasive procedures
Low risk procedure1: 1 day Other procedures than low risk bleeding procedures2: stop 5 days before surgery/invasive procedures
Low risk procedure1: 1 day Other procedures than low risk bleeding procedures2: stop 5 days before surgery/invasive procedures
Low-risk bleeding surgery: 2-day risk of major bleed 0%–2%; High-risk bleeding surgery: 2%–4%.
1Low risk procedure: in case of bleeding, if it occurs, will be low abundance, non-critical in its location and/or easily controlled by simple mechanical hemostasis; 2High risk procedure: the probability of significant bleeding cannot be excluded or, any surgery that is usually hemorrhagic or for which the risk of bleeding would be unacceptable.