Decreased Thioredoxin-1 and Increased HSP90 Expression in Skeletal Muscle in Subjects with Type 2 Diabetes or Impaired Glucose Tolerance

Table 1

Characteristics of the subjects, myosin heavy chain profiles, and variables of glucose metabolism.

Characteristics	IGT	T2D	P value
n = (female/male)	8 (4/4)	10 (4/6)
Age, year	61.4±2.8	62.5±1.6	0.240
BMI	29.7±0.9	29.0±0.5	0.366
VO2max, mL/kg^−1/min^−1	26.1±2.8	26.5±1.9	0.907
Myosin heavy chain profile
MHC I, %	37.3±2.0	58.1±5.0	0.001
MHC IIa, %	42.9±2.8	34.8±4.7	0.081
MHC IIx, %	19.8±2.6	7.0±2.1	0.009
Blood chemistry
Fp-glucose, mmol/L	5.6±0.2	7.1±0.3	0.004
S-insulin, 𝜇U/mL	15.4±3.3	8.4±0.5	0.009
HbA1c, %*	5.7±0.2	6.4±0.1	0.006
HOMA-IR	5.0±0.9	2.7±0.2	0.020
HOMA-beta %	50.2±5.4	20.3±1.4	0.001

Data are given as means ± SE.
∗HbA_1c values (in mmol) are 39 and 46 mmol/mol in the IGT and T2D groups respectively (IFCC-HbA_1c).