In Vitro Ultrastructural Changes of MCF-7 for Metastasise Bone Cancer and Induction of Apoptosis via Mitochondrial Cytochrome C Released by CaCO₃/Dox Nanocrystals

Figure 13

Ultrastructural changes of treated MCF-7 breast cancers showing features of early apoptosis: cell shrinkage and chromatin condensation and late apoptosis: nuclear collapse, progressing blebbing, and apoptotic body formation. Magnification ×10,000; bar 2 μm.