<i>In Vitro</i> Ultrastructural Changes of MCF-7 for Metastasise Bone Cancer and Induction of Apoptosis via Mitochondrial Cytochrome C Released by CaCO<sub><b>3</b></sub>/Dox Nanocrystals

<table>DNA fragmentation assay after treatment with CaCO<sub>3</sub>/Dox for 48 hr. The fragmented DNA was quantified using diphenylamine reagent (colorimetric assay). <svg height="7.9250002" id="M26" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 7.9250002" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>Means with different superscript are statistically significant <svg height="11.375" id="M27" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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q0 -76 10 -138.5t37 -107.5t69 -45q32 0 55.5 25t35.5 68.5t17.5 91.5t5.5 105t-5.5 105.5t-18 92t-36 68t-56.5 24.5z" id="x30"></path></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><path d="M153 550l-26 -186q79 31 111 31q90 0 141.5 -51t51.5 -119q0 -93 -89 -166q-85 -69 -173 -71q-32 0 -61.5 11.5t-41.5 23.5q-18 17 -17 34q2 16 22 33q14 9 26 -1q61 -50 124 -50q60 0 93 43.5t33 104.5q0 69 -41.5 110t-121.5 41q-53 0 -102 -20l38 305h286l6 -8
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</svg> compared to control and CaCO<sub>3</sub>/NP.</table>

BioMed Research International

fig6

Figure 6

Figure 6: <i>In Vitro</i> Ultrastructural Changes of MCF-7 for Metastasise Bone Cancer and Induction of Apoptosis via Mitochondrial Cytochrome C Released by CaCO<sub><b>3</b></sub>/Dox Nanocrystals 

Figure 6 | In Vitro Ultrastructural Changes of MCF-7 for Metastasise Bone Cancer and Induction of Apoptosis via Mitochondrial Cytochrome C Released by CaCO3/Dox Nanocrystals 