Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent

Figure 1

Induction of c-Jun in the axotomized sciatic nerve. (a) c-Jun immunopositive nuclei in the distal rat sciatic nerve segment in vivo 48 h after axotomy (to the left on the section). Scale bar = 500 μm. (b) c-Jun immunoreactivity 10 min to 48 h after axotomy in vivo. The immunopositive nuclei are expressed as a percentage of the total number of nuclei in the nerve sections. Black bars show contralateral control nerve segments, white bars show proximal nerve segments, and grey bars show distal nerve segments. Mean values ± SEM, 𝑛=5. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001.

(a)

(b)