Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent

Figure 6

ATF-3 is induced in SCs by sciatic nerve axotomy in vitro. (a) ATF-3 immunopositive areas in the rat sciatic nerve after 48 hours of culturing (edge of nerve to the left). Scale bar = 500 μm. (b) ATF-3 immunoreactivity in rat sciatic nerve sections after culturing for 10 min to 48 h in vitro. The immunopositive nuclei are expressed as a percentage of the total number of nuclei in the nerve sections. Mean values ± SEM, 𝑛=6. ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001.

(a)

(b)