Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent

Figure 7

Inhibition of MAPK and SAPK in the organotypic sciatic nerve cultures. The effect of the MAPK inhibitor U0126 and the SAPK inhibitor SP600125 on nerve pieces cultured for either 2 h ((a), (b), (c), (d), and (e)) or 48 h ((f), (g), and (h)). The graphs show JNK (a), p-JNK (b), and p-ERK1/2 (e) immunopositive area and c-Jun (c), pc-Jun (d), and ATF-3 (f) immunopositive nuclei. Error bars = mean values ± SEM, 𝑛=6 ((a)–(f)), 𝑛=5 ((g) and (h)). ^∗𝑃<0.05, and ^∗∗𝑃<0.01.

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