Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent
Figure 9
The effect of the SAPK inhibitor SP600125 on ATF-3 upregulation in sciatic nerve segments and DRGs cultured for 48 h. ATF-3 immunoreactivity in a nerve piece (edge of nerve segments to the right) cultured without the inhibitor (a) and with the inhibitor (b). ATF-3 immunoreactivity in a DRG cultured without the inhibitor (c) and with the inhibitor (d). The graphs show ATF-3 immunopositive SC nuclei as of the total area of the nerve section (e) and pc-Jun immunopositive nerve cell nuclei as of the total area of the section of the DRG (f). Error bars = mean values ± SEM, . .
