Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Ingredient (mg)</td><td align="center">Amount (mg)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Atenolol</td><td align="center">50.0</td></tr><tr><td align="left">Xanthan gum </td><td align="center">14.0</td></tr><tr><td align="left">Guar gum </td><td align="center">14.0</td></tr><tr><td align="left">Sodium bicarbonate </td><td align="center">14.0</td></tr><tr><td align="left">Citric acid </td><td align="center">7.0</td></tr><tr><td align="left">Talc </td><td align="center">2.8</td></tr><tr><td align="left">Magnesium stearate </td><td align="center">1.4</td></tr><tr><td align="left">Spray dried lactose </td><td align="center">q.s.</td></tr><tr><td align="left">Tablet weight</td><td align="center">140.0</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>q.s.: quantity sufficient.<br/></td></tr></table>

Composition of atenolol sustained-release tablet formulation.

BioMed Research International

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Table 2

Table 2: Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release 

Table 2 | Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release 