Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release

Table 3

Dissolution efficiency of atorvastatin from solid system with 𝛽-CD prepared using different preparation techniques.

Solid system	Dissolution efficiency; (DE60, %)^a
Atorvastatin-𝛽-CD (1 : 1) physical mixture	56.80±2.31
Atorvastatin-𝛽-CD (1 : 2) physical mixture	61.71±4.28
Atorvastatin-𝛽-CD (1 : 3) physical mixture	71.20±3.39
Atorvastatin-𝛽-CD (1 : 1) solvent evaporation product	69.01±3.03
Atorvastatin-𝛽-CD (1 : 2) solvent evaporation product	84.51±1.56
Atorvastatin-𝛽-CD (1 : 3) solvent evaporation product	96.42±2.69

aCalculated from the area under the dissolution curve after 60 min.