Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release

Table 4

Physical characteristics of bilayer tablets formulation.

Parameter	Experimental value
Drug content (𝑛=3)	Atorvastatin	98.52±2.10%
	Atenolol	98.62±1.63%
Hardness (𝑛=6)	7.30±0.12 kg cm^−2
Friability (𝑛=6)	0.54±0.12%
Weight variation (𝑛=20)	258.2±2.04 mg
Floating lag time (𝑛=6)	8.02±0.42 min
Floating duration (𝑛=6)	12.16±0.57 h