Research Article
Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release
Table 5
Pharmacokinetic parameters for Tonact, Aten, and bilayer tablets (containing 10 mg of atorvastatin and 50 mg of atenolol) after oral administration to healthy rabbit ().
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: time to reach plasma concentration (); AUC: area under plasma concentration-time curve; AUMC: area under the first momentum plasma concentration-time curve; MRT: mean residence time; : plasma half-life of drug; : elimination rate constant. |