RhoA Controls Wnt Upregulation on Microstructured Titanium Surfaces

Figure 1

(a) Total RhoA activation levels in MC3T3 cells growing on Polished or SLA titanium surfaces by G-LISA assay. ^∗𝑃<0.05 versus Polished. (b) Canonical WNT activity by Luciferase reporter assay in C2C12 cells on Polished or SLA surfaces after RhoA inhibition by dominant negative isoform (dnRhoA) or activation by transfection with constitutively active isoform (caRhoA). ^∗𝑃<0.01 versus vehicle-treated Polished; ^#𝑃<0.01 versus vehicle-treated SLA; ^§𝑃<0.01 versus vehicle-treated Polished.

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