Effect of Antioxidants Supplementation on Aging and Longevity

Table 1

Effect of supplementation with natural and synthetic antioxidants on the lifespan of model organisms.

Organism	Additive	Parameter studied	Effect reported	Reference
Saccharomyces cerevisiae, budding yeast	Ascorbic acid	Replicative lifespan of SOD-1 deficient mutant	Partial restoration of normal replicative lifespan	[128]
Saccharomyces cerevisiae	Erythroascorbic acid	Replicative lifespan of wild-type yeast	Little effect	[24]
Saccharomyces cerevisiae	α-tocopherol, CoQ alone, or with α-tocopherol	Replicative lifespan	Decrease increased oxidative stress	[24]
Paramecium tetraurelia	Vitamin E	Clonal lifespan	Increase maximal (382 versus 256 fissions) at 1000 mg/L medium	[129]
Paramecium tetraurelia	Melatonin	Clonal lifespan		[130]
Asplanchna brightwellii,rotifer	Vitamin E (25 ug/mL)	Lifespan	Increase limited to the prereproductive stage [15]	[131]
Philodina acuticornis odiosa, rotifer	Indolepropionamide	Lifespan	Increase up to 3-fold	[13]
Caenorhabditis elegans, nematode	CoQ; Vitamin E	Lifespan	Prolongation	[132]
Caenorhabditis elegans	200 μg/mL vitamin E from hatching to day 3	Survival	Increase (17–23%)	[133]
Caenorhabditis elegans	𝛾-Tocopherol	Lifespan	Slight extension, no effect of 𝛼-tocopherol	[134]
Caenorhabditis elegans	𝛾-, or 𝛼-tocopherol	Lifespan	No effect	[134]
Caenorhabditis elegans	Polydatin, resveratrol-3-O-𝛽-mono-D-glucoside	Mean lifespan	Increase by up to 31% and 62% under normal and acute stress conditions, respectively	[56]
Caenorhabditis elegans	Curcumin	Lifespan	Increase in mev-1 and daf-16 mutants	[135]
Caenorhabditis elegans	Quercetin,; isorhamnetin, and tamarixetin	Lifespan	Increase by 11–16%	[136]
Caenorhabditis elegans	Quercetin-3-O-glucoside	Lifespan	Increase by low concentrations, decrease by high concentrations	[137]
Caenorhabditis elegans	Myricetin,; quercetin, kaempferol, and naringenin	Lifespan	Increase	[90]
Caenorhabditis elegans	Caffeic acid, and; rosmarinic acid	Lifespan	Increase	[138]
Caenorhabditis elegans	Catechin	Mean lifespan, median lifespan	Increase by 9 and 13%, respectively, at 200 𝜇M	[86]
Caenorhabditis elegans	(−)-Epicatechin	Lifespan	No effect	[87]
Caenorhabditis elegans	Epigallocatechin gallate (220 nM)	Mean lifespan	Increase by 10%	[139]
Caenorhabditis elegans	Epigallocatechin gallate	Mean lifespan	Increase under stress conditions but not under normal conditions	[140]
Caenorhabditis elegans	Ferulsinaic acid (0.5–100 𝜇M)	Lifespan	Increase	[141]
Caenorhabditis elegans	Procyanidins from apples (Malus pumila,65 μg/mL)	Mean lifespan	Increase	[87]
Caenorhabditis elegans	Tyrosol	Lifespan	Increase	[21]
Caenorhabditis elegans	Mn-N,N′-bis(salicylidene); ethylenediamide chloride (EUK-8), an SOD mimetic	Lifespan	Extension but only after specific culture conditions	[142]
Caenorhabditis elegans	KPG-7, a herb complex	Lifespan	Prolongation	[143]
Caenorhabditis elegans	EGb 761, extract of Ginkgo  biloba leaves	Mean lifespan	Prolongation	[94]
Caenorhabditis elegans	Royal gelly	Lifespan	Prolongation	[34]
Caenorhabditis elegans	Pt nanoparticles (a SOD/CAT mimetic)	Lifespan	Prolongation	[31]
Drosophila melanogaster	Lipoic acid	Lifespan	Increase	[144]
Drosophila melanogaster	Melatonin	Lifespan	Increase	[145]
Drosophila melanogaster	Epitalon	Lifespan	Increase by 11–16%	[14]
Drosophila melanogaster	Carnosine	Average lifespan	Increase in males, no effect on females	[15]
Drosophila melanogaster	S,S-Trolox-carnosine	Average lifespan	Increase in males (by 16%) and in females (by 36%)	[15]
Drosophila melanogaster	Curcumin, 1 mg/g of medium	Lifespan	Increase	[146]
Drosophila melanogaster	Curcumin, 0.5 and 1.0 mg/g	Lifespan	Increase by 6% and 26% in females and by 16% and 13% in males	[65]
Drosophila melanogaster	Curcumin	Lifespan	Extension, gender- and genotype-specific	[64]
Drosophila melanogaster	Aloe vera extract	Lifespan	Extension	[147]
Drosophila melanogaster	Extract of black rice	Lifespan	Increase by ca 14%	[89]
Drosophila melanogaster	Cacao	Lifespan	Increase	[88]
Drosophila melanogaster	Black tea extract	Mean lifespan	Increase by 10%	[148]
Drosophila melanogaster	EUK-8; Mn 3-methoxy-N,N′-bis(salicyldene); ethylenediamine chloride (EUK-134), mitoquinone	Lifespan	No effect on wild type flies	[149]
Anastrepha ludens, Mexican fruit fly	𝛾-, or 𝛼-Tocopherol	Lifespan	No effect	[134]
Mus musculus, mouse, strain C57BL/6	Vitamin E, lifelong	Median lifespan	Increase by 15%	[150]
Mus musculus	Vitamin E	Lifespan	No effect	[151]
Mus musculus, C3H/He and LAF1	Vitamin E, 0.25% w/w	Lifespan	Increase in mean lifespan, no effect on maximum lifespan	[152]
Mus musculus, SAMP8 (senescence-acceleration prone)	Lipoic acid	Lifespan	Decrease	[45]
Mus musculus, SAMP8	Melatonin	Lifespan	Increase	[153]
Mus musculus	Tetrahydrocurcumin, 0.2% from the age of 13 m	Average lifespan	Increase	[20]
Mus musculus, males from the age of 12 m	LGcombo, complex mixture of botanical extracts, vitamins, and nutraceuticals	Lifespan	No effect	[33]
Mus musculus	A fullerene mimetic of SOD	Lifespan	Prolongation	[32]
Mus musculus	Royal gelly	Lifespan	Increased mean lifespan, no effect on maximal lifespan	[35]
Rattus rattus, rat, Wistar	Epigallocatechin gallate	Median lifespan	Increase by 8–12 weeks (control: 105 weeks)	[77]
Microtus agrestis, field vole	Vitamin C or vitamin E, for 9 m	Lifespan	Decrease	[28]
Mus musculus, Ellobius talpinus (mole vole),; Phodopus campbelli (dwarf hamster)	SkQ1 (mitochondrially targeted plastoquinone derivative)	Survival	Increase	[23]