Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme

Figure 5

A 56-year-old man of GBM with symptomatic radiation necrosis. Before Hypo-IMRT, enhanced lesions were demonstrated in the right frontal lobe on T1-weighted magnetic resonance imaging (MRI) (a). ¹¹C-Methionine positron emission tomography (MET-PET) demonstrated a MET high-uptake on the region (b). 12 months after Hypo-IMRT, the enhanced lesion with perifocal edema was increased in size (c), although MET uptake decreased in the irradiated region (d). Second surgery was performed, and pathological diagnosis was defined as necrotic tissue without viable tumor cells.

(a)

(b)

(c)

(d)