Genotype-Related Effect of Crowding Stress on Blood Pressure and Vascular Function in Young Female Rats

Table 2

Basic vascular parameters, constrictions, and relaxations of the femoral artery in young female Wistar-Kyoto (WKY), borderline hypertensive (BHR), and spontaneously hypertensive (SHR) rats exposed to crowding.

	WKY		BHR		SHR
	Control	Stress	Control	Stress	Control	Stress
ND (μm)	579±12	574±15	630±14	595±10	537±23^+	538±11^+
Basal tension (kPa)	2.04±0.21	1.92±0.26	2.82±0.20	2.24±0.24	2.77±0.53	2.84±0.32
NE—phasic (kPa)	1.34±0.27	2.42±0.47	4.72±0.64^x	3.75±0.53	5.01±1.05^x	5.75±0.73^x+
NE—tonic (kPa)	0.15±0.04	0.35±0.15	6.36±1.78^x	2.36±0.63^x∗	7.42±2.02^x	7.14±1.74^x+
Ser (kPa)	19.0±0.6	19.9±1.1	22.0±1.5	23.7±1.7	23.4±1.7	21.9±1.1
Ser—after L-NAME (kPa)	24.7±0.5^†	24.3±1.7^†	25.0±1.8	28.9±1.8^†	27.7±2.1	27.4±1.3^†
KPSS (kPa)	25.1±1.2	25.0±2.2	26.6±2.7	32.6±2.6^x	34.2±2.8^x+	29.2±2.2
SNP 𝐸max (%)	99±1.1	96±1.3	98±1.5	97±2.0	98.0±2.0	95±2.3
SNP pD2 (−log(mol/L))	7.96±0.05	8.07±0.06	8.09±0.09	7.99±0.11	7.69±0.07^x+	7.63±0.07^x+
ACh 𝐸max (%)	88±1.9	91±1.8	81±1.9	85±2.1	58±1.9^x+	60±1.9^x+
ACh pD2 (−log(mol/L))	7.39±0.04	7.30±0.03	7.50±0.04	7.49±0.05^x	7.36±0.05	7.53±0.05^x

Values represent mean ± SEM of 7–12 rats. ND: normalized diameter of the femoral artery at 13.3 kPa; NE: norepinephrine (10 μmol/L); Ser: serotonin (1 𝜇mol/L); L-NAME: N^G-nitro-L-arginine methyl ester; KPSS: PSS in which NaCl was exchanged for an equimolar concentration of KCl; SNP: sodium nitroprusside; ACh: acetylcholine; ^x𝑃<0.05 versus WKY respective group (control/stress); ⁺𝑃<0.05 versus BHR respective group (control/stress); ^∗𝑃<0.05 versus control group of the same genotype; ^†𝑃<0.05 versus the same group before L-NAME.