CCR7 Regulates Cell Migration and Invasion through JAK2/STAT3 in Metastatic Squamous Cell Carcinoma of the Head and Neck

Table 1

Correlations between CCR7, STAT3 phosphorylation expression and clinicopathological factors of SCCHN.

Clinicopathological characteristics	Number of cases	CCR7		Statistical analysis	STAT3 phosphorylation		Statistical analysis
		+~+++	−		+~+++	−
Age
≥60	40	25	15	= 0.032	25	15	= 0.422
<60	38	23	15		21	17
Gender
Male	50	32	18	= 0.357	30	20	= 0.061
Female	28	16	12		16	12
Tumor size
T1, T2	65	37	28	= 3.510	36	29	= 2.077
T3, T4	13	11	2		10	3
Clinical stage
I, II	37	15	22	= 13.113*	14	23	= 12.998*
III, IV	41	33	8		32	9
Nodal metastasis
Yes	37	29	8	= 8.434*	29	8	= 10.954*
No	41	19	22		17	24

< 0.05 (the internal difference of CCR7 or STAT3 phosphorylation expression within clinicopathological characteristics).