Gastroprotective Effect of Ethanolic Extract of Curcuma xanthorrhiza Leaf against Ethanol-Induced Gastric Mucosal Lesions in Sprague-Dawley Rats

Table 3

Effect of C. xanthorrhiza leaf extract on formation of ulcer area, percentage of inhibition, mucus weight, and amount of prostaglandin E₂ (PGE₂), superoxide dismutase (SOD), and malondialdehyde (MDA) substances in rats.

Group	Pretreatment (5 mL/kg)	Posttreatment	Ulcer area (mm^2) mean ± SEM	Inhibition (%)	Mucus weight (g)	PGE2 (pg/mL)	SOD (U/mL)	MDA (nmol/L)
Normal	CMC	CMC	—	—	0.59±0.031	128.00±0.06	0.552±0.02	17.4±0.008
Ulcer control	CMC	Absolute ethanol	850.00±14.43	—	0.23±0.015	45.50±0.002	0.206±0.03	59.2±0.03
Positive	Omeprazole (20 mg/kg)	Absolute ethanol	178.00±9.60	79.06±0.21	0.46±0.022	97.96±0.006	0.527±0.004	32.58±0.002
Extract	Low dose of extract (250 mg/kg)	Absolute ethanol	0.00±0.00	100.00±0.00	0.37±0.015	81.09±0.04	0.411±0.1	39.7±0.02
Extract	High dose of extract (500 mg/kg)	Absolute ethanol	0.00±0.00	100.00±0.00	0.49±0.012	93.52±0.07	0.461±0.007	25.88±0.01