Gold Nanoparticles Inhibit VEGF₁₆₅-Induced Migration and Tube Formation of Endothelial Cells via the Akt Pathway

Figure 5

The effects of AuNPs on angiogenesis in the CAM. Fertilized eggs were treated with VEGF₁₆₅ in the presence or absence of AuNPs for 48 h and subsequently harvested and photographed. (a) Control; (b) VEGF₁₆₅ (80 nM/egg); (c) VEGF₁₆₅ + AuNPs (1000 nM/egg); (d) VEGF₁₆₅ + AuNPs (1500 nM/egg); (e) angiogenesis was quantified by counting the number of arteriole branches in each photograph. Data are presented as the means ± SEM based on three independent experiments. ^#𝑃<0.05 compared with the control group; ^∗𝑃<0.05 compared with the VEGF₁₆₅ group.

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