Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction

Table 2

miRNAs differentially expressed in the sera from patients with acute myocardial infarction.

miRNA name	Chromosome location	AMI (mean ± SD)	Ctrl. (mean ± SD)	Fold-change (AMI versus Ctrl.)	𝑡-test; 𝑃 value
miRNA upregulated in AMI
miR-193a-5p	17q12	13.15±1.02	11.49±0.48	3.17	0.0016
miR-147b	15q21.1	5.96±1.47	4.34±0.85	3.07	0.0232
miR-497-5p	17p13.1	9.12±0.57	7.58±0.57	2.91	0.0002
miR-542-5p	Xq26.3	6.34±1.07	5.09±1.05	2.36	0.0431
miR-885-3p	3p25.3	11.05±0.99	9.88±0.42	2.25	0.0113
miR-150-3p	19q13.32	9.87±0.66	8.72±0.58	2.21	0.0038
miR-877-5p	6p21.33	13.40±1.06	12.26±0.66	2.20	0.0290
miR-31-5p	9p21.3	7.74±0.84	6.63±0.66	2.17	0.0145
miR-760	1p22.1	13.01±0.91	11.96±0.94	2.07	0.0490
miR-17-3p	13q31.3	7.24±0.23	6.21±0.67	2.04	0.0017
miR-486-3p	8p11.21	9.19±0.66	8.17±0.54	2.02	0.0068
miR-124-3p	8p23.1, 8q12.3	7.23±0.79	6.21±0.90	2.02	0.0390
miRNA downregulated in AMI
miR-20a-5p	13q31.3	7.20±1.00	8.79±0.76	−3.01	0.0045
miR-18a-5p	13q31.3	4.86±0.83	6.41±0.78	−2.94	0.0027
miR-26a-5p	12q14.1, 3p22.2	7.96±0.75	9.38±0.65	−2.69	0.0019
miR-17-5p	13q31.3	8.36±0.92	9.76±0.72	−2.64	0.0066
miR-106a-5p	Xq26.2	6.82±1.15	8.19±0.84	−2.59	0.0216
let-7d-5p	9q22.32	8.44±0.66	9.77±0.65	−2.52	0.0019
miR-191-5p	3p21.31	9.68±0.62	11.01±0.54	−2.51	0.0008
miR-26b-3p	2q35	6.62±1.09	7.91±0.42	−2.44	0.0107
miR-126-3p	9q34.3	9.15±1.17	10.25±0.44	−2.14	0.0340
miR-487b	14q32.31	5.10±0.56	6.16±1.01	−2.09	0.0278
miR-127-3p	14q32.31	6.25±0.71	7.29±0.93	−2.06	0.0313
miR-199a-3p	1q25.1, 19p13.2	7.31±0.60	8.34±0.86	−2.04	0.0205
miR-29c-5p	1q32.2	7.56±0.56	8.57±0.60	−2.02	0.0052

Ctrl.: control; and AMI: acute myocardial infarction.