Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction

Table 3

Validation of differentially expressed serum miRNAs in patients with acute myocardial infarction.

miRNA name	AMI (mean ± SD)	Ctrl. (mean ± SD)	Fold-change (AMI versus Ctrl.)	𝑡-test; 𝑃 value	ROC; AUC	ROC; 𝑃 value
miRNA upregulated in AMI
miR-486-3p	9.79±1.61	8.89±1.66	1.87	0.0310	0.6285	0.0822
miR-150-3p	7.60±1.25	6.88±0.91	1.64	0.0128	0.7154	0.0036
miRNA downregulated in AMI
miR-26a-5p	7.68±1.68	8.61±0.84	−1.90	0.0073	0.6753	0.0177
miR-191-5p	10.23±2.07	11.08±0.96	−1.80	0.0364	0.6524	0.0392
miR-126-3p	8.45±1.61	9.27±0.89	−1.76	0.0126	0.6941	0.0087

Ctrl.: control; AMI: acute myocardial infarction; ROC: receiver operator characteristics; and AUC: area under the curve.