Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction

Table 4

Receiver operator characteristic curve analysis of miRNA ratios in the prediction of acute myocardial infarction.

Combined miRNAs	AMI (mean ± SD)	Ctrl. (mean ± SD)	𝑡-test 𝑃 value	ROC AUC	AUC 95% CI	ROC 𝑃 value	Sensitivity	Specificity
miR-191-5p/miR-486-3p	1.89±1.78	4.42±2.31	1.02𝐸−05	0.8629	0.7648 to 0.9610	<0.0001	83.87%	83.33%
miR-486-3p/miR-126-3p	3.46±2.96	1.06±0.71	4.66𝐸−05	0.8491	0.7531 to 0.9451	<0.0001	61.29%	93.55%
miR-126-3p/miR-150-3p	2.77±4.04	6.52±4.24	7.0𝐸−04	0.8429	0.7423 to 0.9434	<0.0001	93.59%	64.52%
miR-486-3p/miR-26a-5p	6.00±5.03	2.23±2.88	0.0006	0.8205	0.7160 to 0.9250	<0.0001	77.42%	74.19%
miR-26a-5p/miR-150-3p	1.50±1.34	4.50±3.41	2.49𝐸−05	0.8205	0.7166 to 0.9244	<0.0001	83.87%	70.97%
miR-191-5p/miR-150-3p	10.77±12.84	23.01±16.87	0.0021	0.7888	0.6718 to 0.9058	<0.0001	77.42%	77.42%

Ctrl.: control; AMI: acute myocardial infarction; ROC: receiver operator characteristics; and AUC: area under the curve.