Research Article
Systemic Approach to Identify Serum microRNAs as Potential Biomarkers for Acute Myocardial Infarction
Table 4
Receiver operator characteristic curve analysis of miRNA ratios in the prediction of acute myocardial infarction.
| Combined miRNAs | AMI (mean ± SD) | Ctrl. (mean ± SD) | -test value | ROC AUC | AUC 95% CI | ROC value | Sensitivity | Specificity |
| miR-191-5p/miR-486-3p | | | | 0.8629 | 0.7648 to 0.9610 | <0.0001 | 83.87% | 83.33% | miR-486-3p/miR-126-3p | | | | 0.8491 | 0.7531 to 0.9451 | <0.0001 | 61.29% | 93.55% | miR-126-3p/miR-150-3p | | | | 0.8429 | 0.7423 to 0.9434 | <0.0001 | 93.59% | 64.52% | miR-486-3p/miR-26a-5p | | | 0.0006 | 0.8205 | 0.7160 to 0.9250 | <0.0001 | 77.42% | 74.19% | miR-26a-5p/miR-150-3p | | | | 0.8205 | 0.7166 to 0.9244 | <0.0001 | 83.87% | 70.97% | miR-191-5p/miR-150-3p | | | 0.0021 | 0.7888 | 0.6718 to 0.9058 | <0.0001 | 77.42% | 77.42% |
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Ctrl.: control; AMI: acute myocardial infarction; ROC: receiver operator characteristics; and AUC: area under the curve.
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