Amino acid sequence alignment of various members of the RNase A superfamily consensus amino acids is indicated at the bottom of the matrix. Amino acid residues that are essential for catalysis are denoted in yellow boxes and half-cystine residues are noted in pink boxes. <E indicates pyroglutamic acid. Figures to the right of the matrix are the amino acid numberings. hPR, human pancreatic RNase; EDN, eosinophil-derived neurotoxin; ECP, eosinophil cationic protein; ANG, angiogenin.
